Maternal smoking is associated with increased infant oxidative stress at 3 months of age

Paul S Noakes ¹, Richard Thomas ¹, Catherine Lane ¹, Trevor A Mori ², Anne E Barden ², Sunalene G Devadason ¹ and Susan L Prescott ^1*

¹ School of Paediatrics and Child Health, Australia
² School of Medicine and Pharmacology, Australia

^* To whom correspondence should be addressed. E-mail: susanp{at}ichr.uwa.edu.au.

Accepted 31 January 2007

Abstract

Background: Cigarette smoke is a major source of free radicals and oxidative stress. With a significant proportion of women still smoking during pregnancy, this common and avoidable exposure has the potential to influence infant oxidative status, which is implicated in the increased propensity for airway inflammation and asthma. The aim of this study was to examine the effects of maternal smoking on markers of infant oxidative stress.

Methods: We compared the level of oxidative stress (using urinary F2-isoprostanes as a marker of lipid peroxidation) in infants of smokers (n=33) and non- smokers (n=54) at 3 months of age. These groups were balanced for maternal atopy and socioeconomic status. Infant urinary cotinine was also measured as an indicator of early postnatal cigarette smoke exposure.

Results: Maternal smoking was associated with significantly higher infant (P=0.002) cotinine levels, despite the fact that most smoking mothers (83.8%) claimed not to smoke near their baby. Maternal smoking was associated with significantly higher markers of oxidative stress (F2-isoprostane) (P=0.015) at 3 months of age. There was also a positive correlation between urinary F2-isoprostanes and infant urinary cotinine levels (Kendall's tau b, 0.227; P=0.008).

Conclusions: Although this study does not separate the pre- and postnatal effects of smoking, these findings indicate that environmental tobacco smoke in the early postnatal period adversely effects pro- oxidative/antioxidative status within weeks of life in very early infancy.

Keywords: F2-isoprostane, asthma, cotinine, maternal smoking, oxidative stress

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Nagel, G., Arnold, F. J, Wilhelm, M., Link, B., Zoellner, I., Koenig, W. (2009). Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany. Eur Heart J 0: ehp180v1-ehp180 [Abstract] [Full Text]  
• Bush, A. (2008). Update in Pediatric Lung Disease 2007. Am. J. Respir. Crit. Care Med. 177: 686-695 [Full Text]