HYPERSENSITIVITY PNEUMONITIS

Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns

M Kishi, Y Miyazaki, T Jinta, H Furusawa, Y Ohtani, N Inase, Y Yoshizawa

The Department of Integrated Pulmonology, Tokyo Medical and Dental University, Tokyo, Japan

Dr Y Yoshizawa, The Department of Integrated Pulmonology, Tokyo Medical and Dental University, 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan; yoshizawa.pulm{at}tmd.ac.jp

Background: A Th1 predominant immune response has been shown in acute hypersensitivity pneumonitis. Predominance of Th2 appears to favour the development of pulmonary fibrosis through the profibrotic process and has been described as crucial in the progression of idiopathic pulmonary fibrosis. Chronic bird fancier’s lung (cBFL) can present with a histological pattern of usual interstitial pneumonia (UIP)-like lesions. Little is known about the Th1/Th2 balance in the pathogenesis of cBFL.

Methods: To evaluate the relevance of Th1-type chemokines (interferon-inducible protein, IP-10) and Th2-type chemokines (thymus- and activation-regulated chemokine, TARC) and their receptors (CXCR3 and CCR4) to the histological patterns of cBFL, 40 patients with cBFL who underwent surgical lung biopsies, 12 with acute BFL (aBFL) and 10 healthy volunteers were analysed. IP-10 and TARC levels in serum and bronchoalveolar lavage (BAL) fluid were measured by ELISA. Immunohistochemistry for CXCR3 and CCR4 was performed on surgical lung specimens.

Results: The ratio of TARC to IP-10 in the serum of patients with UIP-like lesions was significantly higher than in patients with cNSIP/OP-like lesions, aBFL and healthy volunteers. The ratio of CCR4 to CXCR3 in patients with UIP-like lesions was significantly higher than in those with cNSIP/OP-like lesions and fNSIP-like lesions. The ratio of CCR4-positive to CXCR3-positive cells correlated with the ratio of TARC to IP-10 in serum.

Conclusions: A Th2 predominant immune response may play an important role in the development of UIP-like lesions, as already observed in idiopathic pulmonary fibrosis. A Th1 predominance may play a role in the development of cNSIP/OP-like lesions in cBFL.

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• Miyazaki, Y., Tateishi, T., Akashi, T., Ohtani, Y., Inase, N., Yoshizawa, Y. (2008). Clinical Predictors and Histologic Appearance of Acute Exacerbations in Chronic Hypersensitivity Pneumonitis. Chest 134: 1265-1270 [Abstract] [Full Text]