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Integrated FDG-PET/CT does not make invasive staging of the intrathoracic lymph nodes in non-small cell lung cancer redundant: a prospective study

¹ Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
² Department of Radiology, Ghent University Hospital, Ghent, Belgium
³ Department of Medical Statistics, Ghent University Hospital, Ghent, Belgium
⁴ Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium

Correspondence to:
Correspondence to:
Dr Kurt G Tournoy
Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium; kurt.tournoy{at}ugent.be

Background: Staging of non-small cell lung cancer (NSCLC) is important for determining choice of treatment and prognosis. The accuracy of FDG-PET scans for staging of lymph nodes is too low to replace invasive nodal staging. It is unknown whether the accuracy of integrated FDG-PET/CT scanning makes invasive staging redundant.

Methods: In a prospective study, the mediastinal and/or hilar lymph nodes in patients with proven NSCLC were investigated with integrated FDG-PET/CT scanning. Pathological confirmation of all suspect lymph nodes was obtained to calculate the accuracy of the fusion images. In addition, the use of the standardised uptake value (SUV) in the staging of intrathoracic lymph nodes was analysed.

Results: 105 intrathoracic lymph node stations from 52 patients with NSCLC were characterised. The prevalence of malignancy in the lymph nodes was 36%. The sensitivity of the integrated FDG-PET/CT scan to detect malignant lymph nodes was 84% and its specificity was 85% (positive likelihood ratio 5.64, negative likelihood ratio 0.19). SUV_max, SUV_mean and the SUV_max/SUV_liver ratio were all significantly higher in malignant than in benign lymph nodes. The area under the receiver operating curve did not differ between these three quantitative variables, but the highest accuracy was found with the SUV_max/SUV_liver ratio. At a cut-off value of 1.5 for the SUV_max/SUV_liver ratio, the sensitivity and specificity to detect malignant lymph node invasion were 82% and 93%, respectively.

Conclusion: The accuracy of integrated FDG-PET/CT scanning is too low to replace invasive intrathoracic lymph node staging in patients with NSCLC. The visual interpretation of the fusion images of the integrated FDG-PET/CT scan can be replaced by the quantitative variable SUV_max/SUV_liver without loss of accuracy for intrathoracic lymph node staging.

Abbreviations: CT, computed tomography; EBUS-TBNA, endobronchial endoscopic ultrasound with real-time guided transbronchial needle aspiration; EUS-FNA, endoscopic ultrasound with real-time guided fine needle aspiration; FDG, 18-fluoro-2-deoxy-D-glucose; NSCLC, non-small cell lung cancer; PET, positron emission tomography; ROC, receiver operating curve; SUV, standardised uptake value

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