REVIEW SERIES

Challenges in pulmonary fibrosis · 1: Use of high resolution CT scanning of the lung for the evaluation of patients with idiopathic interstitial pneumonias

Michael B Gotway¹, Michelle M Freemer², Talmadge E King, Jr²

¹ Department of Radiology, University of California at San Francisco, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, California, USA
² Department of Medicine, University of California at San Francisco, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, California, USA

Correspondence to:
Correspondence to:
Dr Michael Gotway
Scottsdale Medical Imaging, and affiliate of Southwest Diagnostic Imaging, 3501 North Scottsdale Road, Suite 130, Box 1573, Scottsdale, AZ 85251, USA

High resolution CT (HRCT) scanning has contributed significantly to the evaluation of patients with interstitial lung disease and is particularly useful in the diagnosis of idiopathic pulmonary fibrosis (IPF). The characteristic radiographic features of the idiopathic interstitial pneumonias on HRCT scans have been increasingly analysed and are now fairly well described. Based on current data, HRCT scanning can provide a confident, highly specific diagnosis of IPF in many patients with diffuse lung disease. This article reviews an organised approach to HRCT scanning and identifies the features that allow an accurate diagnosis of the idiopathic interstitial pneumonias to be made. The role of surgical lung biopsy is discussed in the diagnosis of cases when a definite HRCT diagnosis cannot be made.

Abbreviations: AIP, acute interstitial pneumonia; COP, cryptogenic organising pneumonia; DIP, desquamative interstitial pneumonia; HRCT, high resolution CT; IIP, idiopathic interstitial pneumonia; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; LIP, lymphocytic interstitial pneumonia; NSIP, non-specific interstitial pneumonia; RB-ILD, respiratory bronchiolitis-interstitial lung disease; UIP, usual interstitial pneumonia

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Tager, A. M., Sharma, A., Mark, E. J. (2009). Case 32-2009 -- A 27-Year-Old Man with Progressive Dyspnea. NEJM 361: 1585-1593 [Full Text]  
• Groves, A. M., Win, T., Screaton, N. J., Berovic, M., Endozo, R., Booth, H., Kayani, I., Menezes, L. J., Dickson, J. C., Ell, P. J. (2009). Idiopathic Pulmonary Fibrosis and Diffuse Parenchymal Lung Disease: Implications from Initial Experience with 18F-FDG PET/CT. JNM 50: 538-545 [Abstract] [Full Text]  
• Moeller, A., Gilpin, S. E., Ask, K., Cox, G., Cook, D., Gauldie, J., Margetts, P. J., Farkas, L., Dobranowski, J., Boylan, C., O'Byrne, P. M., Strieter, R. M., Kolb, M. (2009). Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 179: 588-594 [Abstract] [Full Text]  
• Wells, A U, Hirani, N, on behalf of the BTS Interstitial Lung Disease Gui, (2008). Interstitial lung disease guideline. Thorax 63: v1-v58 [Full Text]  
• Reich, J. M., Noth, I., Martinez, F. J. (2008). Genesis of Some Histologic, BAL, and Auscultatory Features of Idiopathic Pulmonary Fibrosis. Chest 133: 585-586 [Full Text]