CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease

J P Fuld^1,2, L P Kilduff^1,3, J A Neder¹, Y Pitsiladis¹, M E J Lean⁴, S A Ward^1,5 and M M Cotton²

¹ Centre for Exercise Science and Medicine, Institute of Biological and Life Sciences, University of Glasgow, Glasgow, UK
² Department of Respiratory Medicine, Glasgow Royal Infirmary, Glasgow, UK
³ Department of Sports Science, University of Wales, Swansea, UK
⁴ Department of Human Nutrition, University of Glasgow, Glasgow, UK
⁵ School of Sport and Exercise Sciences, University of Leeds, Leeds, UK

Correspondence to:
Correspondence to:
Dr J P Fuld
Department of Cystic Fibrosis and Lung Defence, Papworth Hospital, Papworth Everard, Cambridgeshire CB3 8RE, UK; j.fuld{at}dsl.pipex.com

Background: Skeletal muscle wasting and dysfunction are strong independent predictors of mortality in patients with chronic obstructive pulmonary disease (COPD). Creatine nutritional supplementation produces increased muscle mass and exercise performance in health. A controlled study was performed to look for similar effects in 38 patients with COPD.

Methods: Thirty eight patients with COPD (mean (SD) forced expiratory volume in 1 second (FEV₁) 46 (15)% predicted) were randomised to receive placebo (glucose polymer 40.7 g) or creatine (creatine monohydrate 5.7 g, glucose 35 g) supplements in a double blind trial. After 2 weeks loading (one dose three times daily), patients participated in an outpatient pulmonary rehabilitation programme combined with maintenance (once daily) supplementation. Pulmonary function, body composition, and exercise performance (peripheral muscle strength and endurance, shuttle walking, cycle ergometry) took place at baseline (n = 38), post loading (n = 36), and post rehabilitation (n = 25).

Results: No difference was found in whole body exercise performance between the groups: for example, incremental shuttle walk distance mean –23.1 m (95% CI –71.7 to 25.5) post loading and –21.5 m (95% CI –90.6 to 47.7) post rehabilitation. Creatine increased fat-free mass by 1.09 kg (95% CI 0.43 to 1.74) post loading and 1.62 kg (95% CI 0.47 to 2.77) post rehabilitation. Peripheral muscle performance improved: knee extensor strength 4.2 N.m (95% CI 1.4 to 7.1) and endurance 411.1 J (95% CI 129.9 to 692.4) post loading, knee extensor strength 7.3 N.m (95% CI 0.69 to 13.92) and endurance 854.3 J (95% CI 131.3 to 1577.4) post rehabilitation. Creatine improved health status between baseline and post rehabilitation (St George’s Respiratory Questionnaire total score –7.7 (95% CI –14.9 to –0.5)).

Conclusions: Creatine supplementation led to increases in fat-free mass, peripheral muscle strength and endurance, health status, but not exercise capacity. Creatine may constitute a new ergogenic treatment in COPD.

Abbreviations: BMI, body mass index; CWR, constant work rate exercise test; ESWT, endurance shuttle walk test; FEV₁, forced expiratory volume in 1 second; FFM, fat-free mass, FM, fat mass; FVC, forced vital capacity; IET, incremental exercise test; ISWT, incremental shuttle walk test; MIP, maximum inspiratory pressure; MVV, maximum voluntary ventilation; PCr, phosphocreatine; RPE, rating of perceived exertion; SGRQ, St George’s Respiratory Questionnaire; TLCO, carbon monoxide transfer factor; V^·O₂, peak oxygen uptake

Keywords: creatine; pulmonary rehabilitation; chronic obstructive pulmonary disease; exercise tolerance; fat-free mass; quality of life

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Airwaves

Wisia Wedzicha
Thorax 2005 60: 525. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Maltais, F., Saey, D., Debigare, R. (2008). Enhancing the Benefits of Pulmonary Rehabilitation: Doing More for a Few or Doing a Little Less for Many?. Am. J. Respir. Crit. Care Med. 178: 215-216 [Full Text]  
• Deacon, S. J., Vincent, E. E., Greenhaff, P. L., Fox, J., Steiner, M. C., Singh, S. J., Morgan, M. D. (2008). Randomized Controlled Trial of Dietary Creatine as an Adjunct Therapy to Physical Training in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 178: 233-239 [Abstract] [Full Text]  
• Albert, P., Calverley, P. M. A. (2008). Drugs (including oxygen) in severe COPD. Eur Respir J 31: 1114-1124 [Abstract] [Full Text]  
• Wagner, P. D. (2008). Possible mechanisms underlying the development of cachexia in COPD. Eur Respir J 31: 492-501 [Abstract] [Full Text]  
• Cazzola, M., MacNee, W., Martinez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M. A., Celli, B. R., Jones, P. W., Mahler, D. A., Make, B., Miravitlles, M., Page, C. P., Palange, P., Parr, D., Pistolesi, M., Rennard, S. I., Rutten-van Molken, M. P., Stockley, R., Sullivan, S. D., Wedzicha, J. A., Wouters, E. F., on behalf of the American Thoracic Society/Europea, (2008). Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J 31: 416-469 [Abstract] [Full Text]  
• Vieira, R. P., Duarte, A. C. S., Claudino, R. C., Perini, A., Santos, A. B. G., Moriya, H. T., Arantes-Costa, F. M., Martins, M. A., Carvalho, C. R. F., Dolhnikoff, M. (2007). Creatine Supplementation Exacerbates Allergic Lung Inflammation and Airway Remodeling in Mice. Am. J. Respir. Cell Mol. Bio. 37: 660-667 [Abstract] [Full Text]  
• Swallow, E. B., Gosker, H. R., Ward, K. A., Moore, A. J., Dayer, M. J., Hopkinson, N. S., Schols, A. M. W. J., Moxham, J., Polkey, M. I. (2007). A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans. J. Appl. Physiol. 103: 739-746 [Abstract] [Full Text]  
• Deacon, SarahJ., Vincent, EmmaE., Singh, SallyJ., Steiner, MichaelC., Greenhaff, P., Morgan, MichaelD. (2006). Does creatine supplementation enhance the effects of physical training during pulmonary rehabilitation in COPD?. ERR 15: 187-189 [Abstract] [Full Text]  
• Hill, N. S. (2006). Pulmonary rehabilitation.. Proc Am Thorac Soc 3: 66-74 [Abstract] [Full Text]  
• Griffiths, T L, Proud, D (2005). Creatine supplementation as an exercise performance enhancer for patients with COPD? An idea to run with. Thorax 60: 525-526 [Full Text]