ASTHMA

Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City

I Romieu¹, J J Sienra-Monge², M Ramírez-Aguilar¹, H Moreno-Macías¹, N I Reyes-Ruiz², B Estela del Río-Navarro², M Hernández-Avila¹, S J London³

¹ Instituto Nacional de Salud Publica de México, Cuernavaca, Mexico
² Hospital Infantil "Federico Gómez", México
³ National Institute of Environmental Health (NIEHS), NC, USA

Correspondence to:
Correspondence to:
Dr I Romieu
Instituto Nacional de Salud Publica, 655 Avenida Universidad, Col. Santa Maria Ahuacatitlán, 62508 Cuernavaca, Morelos, México; iromieu{at}correo.insp.mx

Background: We recently reported that antioxidant supplementation with vitamins C and E mitigated ozone related decline in forced expiratory flow (FEF_25–75) in 158 asthmatic children in an area with high ozone exposure in Mexico City.

Methods: A study was undertaken to determine whether deletion of glutathione S-transferase M1 (GSTM1 null genotype), a gene involved in response to oxidative stress, influences ozone related decline in FEF_25–75 and the benefit of antioxidant supplementation.

Results: GSTM1 null children receiving placebo had significant ozone related decrements in FEF_25–75 (percentage change per 50 ppb of ozone 2.9 (95% CI -5.2 to -0.6), p = 0.01); GSTM1 positive children did not. Conversely, the effect of antioxidants was stronger in children with the GSTM1 null genotype.

Conclusions: Asthmatic children with a genetic deficiency of GSTM1 may be more susceptible to the deleterious effects of ozone on the small airways and might derive greater benefit from antioxidant supplementation.

Keywords: GSTM1; asthma; antioxidant; diet; children; genetics

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