REVIEW SERIES

Chronic obstructive pulmonary disease • 3: Experimental animal models of pulmonary emphysema

R Mahadeva^1,2, S D Shapiro

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
² Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02116, USA

Correspondence to:
Dr R Mahadeva, Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK;
rm232{at}cam.ac.uk

The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.

Keywords: pulmonary emphysema; chronic obstructive pulmonary disease animal models

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