Case report
Lymphoid interstitial pneumonitis associated with common variable
hypogammaglobulinaemia treated with cyclosporin A
Christopher W H Daviesa, Mark C Junipera, Winifred Grayc, Fergus V Gleesonb, Helen M Chapeld, Robert J O Daviesa
a Osler Chest Unit,
Churchill Hospital, Oxford Radcliffe Trust, Oxford OX3 7LJ, UK, b Department of Radiology, c Department of Cellular Pathology, John Radcliffe
Hospital, Oxford Radcliffe Trust, Oxford OX3 9DU, UK, d Department
of Immunology
Correspondence to: Dr CWH Davies
Received 9 October 1997; Returned to authors 21 January 1998; Revised version received 25 February 1998; Accepted for publication 16 March 1998
Lymphoid interstitial pneumonitis (LIP) is a rare
clinicopathological entity that may be associated with common variable
immune deficiency (CVID) and may lead to respiratory failure and death. Some patients may respond to prolonged corticosteroid treatment. We
hypothesised that, in view of the predominant T cell nature of LIP,
cyclosporin A would be a more appropriate choice of immunosuppressive agent and report the first case of its successful use in a woman with
LIP associated with CVID.
Keywords: lymphoid interstitial pneumonitis; common variable immune deficiency; cyclosporin A
© 2000 by Thorax
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