Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis
a Department of Medicine, National
Kinki Central Hospital, Nagasonecho 1180, Sakai City, Osaka 591, Japan, b Department of Geriatric
Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita City,
Osaka, 565, Japan, c Department of Medicine,
Osaka Prefectural Hospital, Manndai Higashi 3-1-56, Sumiyosu-ku, Osaka
City, 558 Japan
Correspondence to: Dr Y Takemoto.
Received 15 September 1997; Returned to authors 24 November 1997; Revised version received 3 February 1998; Accepted for publication 9 February 1998
BACKGROUND
Serum angiotensin converting enzyme
(SACE) is considered to reflect disease activity in sarcoidosis. SACE
activity is increased in many patients with active sarcoid lesions. The
mechanism for the increased SACE activity in this disease has not been
clarified. ACE insertion/deletion (I/D) gene polymorphism has been
reported to have an association with SACE levels in sarcoidosis, but no evidence of an association between angiotensin II receptor gene polymorphism and SACE in this disease has been found. A study of the
association of angiotensin II receptor gene polymorphisms with
sarcoidosis was therefore undertaken.
METHODSACE (I/D), angiotensin II type 1 receptor
(AGTR1), and angiotensin II type 2 receptor (AGTR2 ) gene polymorphisms
were investigated by polymerase chain reaction (PCR) and SACE levels
were measured in three groups of patients: those with sarcoidosis or
tuberculosis and normal controls.
RESULTSThere was no difference in allele
frequency of AGTR1 and AGTR2 polymorphism among the three groups.
Neither AGTR1 nor AGTR2 polymorphisms were associated with sarcoidosis.
SACE activity was higher in patients with sarcoidosis with the AGTR1
A/C genotype than in others. However, this tendency was not detected in
patients with tuberculosis.
CONCLUSIONSThe AGTR1 allele C is associated with
high activity of SACE in patients with sarcoidosis. It is another
predisposing factor for high levels of SACE in patients with
sarcoidosis and is considered to be an independent factor from the ACE
D allele for high levels of SACE in sarcoidosis. This fact could be one
of the explanations for the increased SACE activity in sarcoidosis.
© 1998 by Thorax
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