Ciliary beat frequency in transplanted lungs.

D Veale, P N Glasper, A Gascoigne, J H Dark, G J Gibson, P A Corris

Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne.

BACKGROUND--Patients with lung transplantation are prone to respiratory infections. Generally this is attributable to the effects of immunosuppressive drugs but mucociliary clearance has been found to be impaired in these subjects. A study was performed to determine whether this finding is accompanied by a reduction in ciliary beat frequency (CBF). METHODS--Six patients who had undergone single lung transplantation for fibrosing lung disease were investigated. CBF was measured in mucosal samples from native and transplanted bronchi by a videophotometry method. RESULTS--The CBF was reduced in the transplanted bronchi in all cases when both fastest and slowest beating cilia were examined. The fastest beating cilia on the native side had a mean (SD) CBF of 12.1 (1.3) Hz compared with 9.6 (2.0) Hz on the transplanted side. The slowest beating cilia also had reduced CBF on the transplanted side. CONCLUSION--In patients with fibrotic lung disease, CBF is reduced in transplanted bronchi in comparison with native bronchi.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Pazetti, R., Pego-Fernandes, P. M., Lorenzi-Filho, G., Saldiva, P. H.N., Moreira, L. F. P., Jatene, F. B. (2008). Effects of Cyclosporine A and Bronchial Transection on Mucociliary Transport in Rats. Ann. Thorac. Surg. 85: 1925-1929 [Abstract] [Full Text]  
• Walters, E. H., Reid, D. W., Johns, D. P., Ward, C. (2007). Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling. Eur Respir J 30: 574-588 [Abstract] [Full Text]  
• Ward, C, Forrest, I A, Brownlee, I A, Johnson, G E, Murphy, D M, Pearson, J P, Dark, J H, Corris, P A (2005). Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 60: 872-874 [Abstract] [Full Text]  
• Cantu, E. III, Appel, J. Z. III, Hartwig, M. G., Woreta, H., Green, C., Messier, R., Palmer, S. M., Davis, R. D. Jr (2004). Early Fundoplication Prevents Chronic Allograft Dysfunction in Patients with Gastroesophageal Reflux Disease. Ann. Thorac. Surg. 78: 1142-1151 [Abstract] [Full Text]  
• Davis, R. D. Jr, Lau, C. L., Eubanks, S., Messier, R. H., Hadjiliadis, D., Steele, M. P., Palmer, S. M. (2003). Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J. Thorac. Cardiovasc. Surg. 125: 533-542 [Abstract] [Full Text]  
• Rivero, D. H. R. F., Lorenzi-Filho, G., Pazetti, R., Jatene, F. B., Saldiva, P. H. N. (2001). Effects of Bronchial Transection and Reanastomosis on Mucociliary System. Chest 119: 1510-1515 [Abstract] [Full Text]  
• Norgaard, M. A., B. Andersen, C., Pettersson, G. (1999). Airway epithelium of transplanted lungs with and without direct bronchial artery revascularization. Eur. J. Cardiothorac. Surg. 15: 37-44 [Abstract] [Full Text]