Bone mineral density and body composition in adult patients with cystic fibrosis.

A B Grey, R W Ames, R D Matthews, I R Reid

Department of Medicine, University of Auckland, New Zealand.

BACKGROUND--Cystic fibrosis is a multisystem disease characterised by chronic pulmonary sepsis and malnutrition. To ascertain whether osteoporosis is a feature of cystic fibrosis in adult patients, total body and regional bone mineral density (BMD) was measured in a group of eight men and eight women aged 17-42 years. METHODS--Total body and regional BMD (lumbar spine L2-L4, femoral neck, trochanteric, and Ward's triangle), as well as total body fat and lean mass, were measured by dual energy x ray absorptiometry. A range of biochemical, lifestyle, and anthropometric variables was also assessed. RESULTS--Patients with cystic fibrosis had significantly reduced bone density at all sites compared with normal young adults. The mean reductions ranged from 7% at Ward's triangle to 13% at the trochanter. Body mass index (BMI) was positively correlated with BMD at four sites and disease severity negatively correlated with BMD at two sites. Other biochemical and anthropometric variables were not predictive of bone density. Total body fat mass was reduced by 30% compared with normal young adults. CONCLUSIONS--Bone density is decreased in adult patients with cystic fibrosis and BMI and disease severity are independent predictors of bone density.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Osteoporosis and cystic fibrosis.

T C Stamp and D M Geddes
Thorax 1993 48: 585-586. [PDF]

This article has been cited by other articles:

• Lyu, D. M., Zamora, M. R. (2009). Medical Complications of Lung Transplantation. Proc Am Thorac Soc 6: 101-107 [Abstract] [Full Text]  
• Ward, K. A, Ashby, R. L, Roberts, S. A, Adams, J. E, Zulf Mughal, M (2007). UK reference data for the Hologic QDR Discovery dual-energy x ray absorptiometry scanner in healthy children and young adults aged 6-17 years. Arch. Dis. Child. 92: 53-59 [Abstract] [Full Text]  
• Boyle, M. P., Noschese, M. L., Watts, S. L., Davis, M. E., Stenner, S. E., Lechtzin, N. (2005). Failure of High-Dose Ergocalciferol to Correct Vitamin D Deficiency in Adults with Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 172: 212-217 [Abstract] [Full Text]  
• Aris, R. M., Merkel, P. A., Bachrach, L. K., Borowitz, D. S., Boyle, M. P., Elkin, S. L., Guise, T. A., Hardin, D. S., Haworth, C. S., Holick, M. F., Joseph, P. M., O'Brien, K., Tullis, E., Watts, N. B., White, T. B. (2005). Guide to Bone Health and Disease in Cystic Fibrosis. J. Clin. Endocrinol. Metab. 90: 1888-1896 [Abstract] [Full Text]  
• Barry, S. C., Gallagher, C. G. (2003). Corticosteroids and skeletal muscle function in cystic fibrosis. J. Appl. Physiol. 95: 1379-1384 [Abstract] [Full Text]  
• Katsura, H., Kida, K. (2002). A Comparison of Bone Mineral Density in Elderly Female Patients With COPD and Bronchial Asthma. Chest 122: 1949-1955 [Abstract] [Full Text]  
• Haworth, C S, Selby, P L, Horrocks, A W, Mawer, E B, Adams, J E, Webb, A K (2002). A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 57: 719-723 [Abstract] [Full Text]  
• IONESCU, A. A., NIXON, L. S., LUZIO, S., LEWIS-JENKINS, V., EVANS, W. D., STONE, M. D., OWENS, D. R., ROUTLEDGE, P. A., SHALE, D. J. (2002). Pulmonary Function, Body Composition, and Protein Catabolism in Adults with Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 165: 495-500 [Abstract] [Full Text]  
• Haslam, R H M, Borovnicar, D J, Stroud, D B, Strauss, B J G, Bines, J E (2001). Correlates of prepubertal bone mineral density in cystic fibrosis. Arch. Dis. Child. 85: 166-171 [Abstract] [Full Text]  
• Feldman, C., Anderson, R., Theron, A.J., Steel, H.C., van Rensburg, C.E.J., Cole, P.J., Wilson, R. (2001). Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. Eur Respir J 18: 122-129 [Abstract] [Full Text]  
• Soyka, L. A., Fairfield, W. P., Klibanski, A. (2000). Hormonal Determinants and Disorders of Peak Bone Mass in Children. J. Clin. Endocrinol. Metab. 85: 3951-3963 [Full Text]  
• ARIS, R. M., STEPHENS, A. R., ONTJES, D. A., DENENE BLACKWOOD, A., LARK, R. K., HENSLER, M. B., NEURINGER, I. P., LESTER, G. E. (2000). Adverse Alterations in Bone Metabolism Are Associated with Lung Infection in Adults with Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 162: 1674-1678 [Abstract] [Full Text]  
• IONESCU, A. A., NIXON, L. S., EVANS, W. D., STONE, M. D., LEWIS-JENKINS, V., CHATHAM, K., SHALE, D. J. (2000). Bone Density, Body Composition, and Inflammatory Status in Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 162: 789-794 [Abstract] [Full Text]  
• Conway, S P, Morton, A M, Oldroyd, B, Truscott, J G, White, H, Smith, A H, Haigh, I (2000). Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 55: 798-804 [Abstract] [Full Text]  
• Haworth, C. S., Webb, A. K., Egan, J. J., Selby, P. L., Hasleton, P. S., Bishop, P. W., Freemont, T. J. (2000). Bone Histomorphometry in Adult Patients With Cystic Fibrosis. Chest 118: 434-439 [Abstract] [Full Text]  
• Spira, A., Gutierrez, C., Chaparro, C., Hutcheon, M. A., Chan, C. K.N. (2000). Osteoporosis and Lung Transplantation: A Prospective Study. Chest 117: 476-481 [Abstract] [Full Text]  
• Haworth, C S, Selby, P L, Webb, A K, Dodd, M E, Musson, H, Niven, R M., Economou, G, Horrocks, A W, Freemont, A J, Mawer, E B, Adams, J E (1999). Low bone mineral density in adults with cystic fibrosis. Thorax 54: 961-967 [Abstract] [Full Text]  
• Laursen, E M, Mølgaard, C, Michaelsen, K F, Koch, C, Müller, J (1999). Bone mineral status in 134 patients with cystic fibrosis. Arch. Dis. Child. 81: 235-240 [Abstract] [Full Text]  
• Giembycz, M. A., Lindsay, M. A. (1999). Pharmacology of the Eosinophil. Pharmacol. Rev. 51: 213-340 [Abstract] [Full Text]  
• DONOVAN, D. S. Jr., PAPADOPOULOS, A., STARON, R. B., ADDESSO, V., SCHULMAN, L., MCGREGOR, C., COSMAN, F., LINDSAY, R. L., SHANE, E. (1998). Bone Mass and Vitamin D Deficiency in Adults with Advanced Cystic Fibrosis Lung Disease. Am. J. Respir. Crit. Care Med. 157: 1892-1899 [Abstract] [Full Text]  
• EVANS, D. J., BARNES, P. J., CLUZEL, M., O'CONNOR, B. J. (1997). Effects of a Potent Platelet-activating Factor Antagonist, SR27417A, on Allergen-induced Asthmatic Responses. Am. J. Respir. Crit. Care Med. 156: 11-16 [Abstract] [Full Text]