Thorax

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Troyer, A.
Right arrow Articles by Cordier, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Troyer, A.
Right arrow Articles by Cordier, R.

Thorax, Vol 35, 603-610, Copyright © 1980 by Thorax.


PAPERS

Analysis of lung volume restriction in patients with respiratory muscle weakness

A De Troyer, S Borenstein and R Cordier

We investigated pulmonary mechanics in 25 patients, 9 to 55 years of age, with a variety of generalised neuromuscular diseases and variable degrees of respiratory muscle weakness. The average degree of inspiratory muscle force was 39.2% (range 8-83%) of predicted. The lung volume restriction far exceeded that expected for the degree of muscle weakness: the observed decrement in respiratory muscle force should, theoretically, decrease vital capacity to 78% of its control value, while the mean VC in our patients was only 50% of predicted. Analysis of lung pressure-volume curves indicated that the two principal causes of the disproportionate loss of lung volume were a reduction in lung distensibility probably caused by widespread microatelectasis, and a decrease in the outward pull of the chest wall. Because it reflects both direct (loss of distending pressure) and secondary (alterations in the elastic properties of the lungs and chest wall) effects of respiratory muscle weakness on lung function, we conclude that, in these patients, the vital capacity remains the most useful measurement to follow evolution of the disease process or response to treatment.


This article has been cited by other articles:


Home page
Am. J. Respir. Crit. Care Med.Home page
F. Nicot, N. Hart, V. Forin, M. Boule, A. Clement, M. I. Polkey, F. Lofaso, and B. Fauroux
Respiratory Muscle Testing: A Valuable Tool for Children with Neuromuscular Disorders
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 67 - 74.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
N. Lechtzin, D. Shade, L. Clawson, and C. M. Wiener
Supramaximal Inflation Improves Lung Compliance in Subjects With Amyotrophic Lateral Sclerosis
Chest, May 1, 2006; 129(5): 1322 - 1329.
[Abstract] [Full Text] [PDF]


Home page
Mult SclerHome page
K Rasova, P Brandejsky, E Havrdova, M Zalisova, and P Rexova
Spiroergometric and spirometric parameters in patients with multiple sclerosis: are there any links between these parameters and fatigue, depression, neurological impairment, disability, handicap and quality of life in multiple sclerosis?
Multiple Sclerosis, April 1, 2005; 11(2): 213 - 221.
[Abstract] [PDF]


Home page
ChestHome page
G. J. Schilero, D. R. Grimm, W. A. Bauman, R. Lenner, and M. Lesser
Assessment of Airway Caliber and Bronchodilator Responsiveness in Subjects With Spinal Cord Injury
Chest, January 1, 2005; 127(1): 149 - 155.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
N. Laws and A. Hoey
Progression of kyphosis in mdx mice
J Appl Physiol, November 1, 2004; 97(5): 1970 - 1977.
[Abstract] [Full Text] [PDF]


Home page
J. Neurol. Neurosurg. PsychiatryHome page
N Hart, M I Polkey, T Sharshar, L Falaize, B Fauroux, J C Raphael, and F Lofaso
Limitations of sniff nasal pressure in patients with severe neuromuscular weakness
J. Neurol. Neurosurg. Psychiatry, December 1, 2003; 74(12): 1685 - 1687.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
F. Laghi and M. J. Tobin
Disorders of the Respiratory Muscles
Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
N. Hart, D. Cramer, S.P. Ward, A.H. Nickol, J. Moxham, M.I. Polkey, and N.B. Pride
Effect of pattern and severity of respiratory muscle weakness on carbon monoxide gas transfer and lung volumes
Eur. Respir. J., October 1, 2002; 20(4): 996 - 1002.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Statement on Respiratory Muscle Testing
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 518 - 624.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
N. Hart, A. H. Nickol, D. Cramer, S. P. Ward, F. Lofaso, N. B. Pride, J. Moxham, and M. I. Polkey
Effect of Severe Isolated Unilateral and Bilateral Diaphragm Weakness on Exercise Performance
Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1265 - 1270.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
B. Lanini, G. Misuri, F. Gigliotti, I. Iandelli, A. Pizzi, I. Romagnoli, and G. Scano
Perception of Dyspnea in Patients With Neuromuscular Disease
Chest, August 1, 2001; 120(2): 402 - 408.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
V. Ugalde, S. Walsh, R. T. Abresch, H. W. Bonekat, and E. Breslin
Respiratory abdominal muscle recruitment and chest wall motion in myotonic muscular dystrophy
J Appl Physiol, July 1, 2001; 91(1): 395 - 407.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
A. Baydur, M. Alsalek, S. G. Louie, and O. P. Sharma
Respiratory Muscle Strength, Lung Function, and Dyspnea in Patients With Sarcoidosis
Chest, July 1, 2001; 120(1): 102 - 108.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
S.-W. Kang and J. R. Bach
Maximum Insufflation Capacity
Chest, July 1, 2000; 118(1): 61 - 65.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
J. R. Bach and S.-W. Kang
Disorders of Ventilation : Weakness, Stiffness, and Mobilization
Chest, February 1, 2000; 117(2): 301 - 303.
[Full Text] [PDF]


Home page
ChestHome page
G. Misuri, B. Lanini, F. Gigliotti, I. Iandelli, A. Pizzi, M. G. Bertolini, and G. Scano
Mechanism of CO2 Retention in Patients With Neuromuscular Disease
Chest, February 1, 2000; 117(2): 447 - 453.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
P. BGIN, J. MATHIEU, J. ALMIRALL, and A. GRASSINO
Relationship Between Chronic Hypercapnia and Inspiratory-Muscle Weakness in Myotonic Dystrophy
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 133 - 139.
[Abstract] [Full Text]


Home page
Neurorehabil Neural RepairHome page
G. Demirel, S. Demirel, H. Yilmaz, N. Kesiktas, and V. Akkaya
Pulmonary Function in Spinal Cord Injury: A Clinical and Spirometric Study
Neurorehabil Neural Repair, January 1, 1997; 11(3): 159 - 168.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1980 BMJ Publishing Group Ltd & British Thoracic Society