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Thorax 1975;30:204-219; doi:10.1136/thx.30.2.204
Copyright © 1975 BMJ Publishing Group Ltd & British Thoracic Society.

Respiratory disease caused by synthetic fibres: a new occupational disease.

J C Pimentel, R Avila, A G Lourenço

Seven patients exposed to the inhalation of synthetic fibres presented with various bronchopulmonary diseases, such as asthma, extrinsic allergic alveolitis, chronic bronchitis with bronchiectasis, spontaneous pneumothorax, and chronic pneumonia. The histological features are described and an attempt has been made to set up immunological techniques for the diagnosis. A series of histochemical techniques, based on textile chemistry, are proposed for the identification of the inclusions found in bronchopulmonary lesions. The results of the experimental production of the disease in guinea-pigs by the inhalation of synthetic fibre dusts are presented. The prognosis of these cases is good in the acute or recently established cases but is poor when widespread and irreversible fibrosis has set in. The authors consider that pulmonary disease due to inhaled particles is probably set off by an individual factor, possibly immunological.


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This article has been cited by other articles:

  • Ghio, A. J., Funkhouser, W., Pugh, C. B., Winters, S., Stonehuerner, J. G., Mahar, A. M., Roggli, V. L. (2006). Pulmonary Fibrosis and Ferruginous Bodies Associated with Exposure to Synthetic Fibers. Toxicol Pathol 34: 723-729 [Abstract] [Full Text]  
  • BOUHUYS, A. (1975). Fibers and Fibrosis. ANN INTERN MED 83: 898-899 [Abstract]  

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